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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3742
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sparc
Name: secreted protein acidic and cysteine rich
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sparcaffects expressionISOSparc (Mus musculus)6480464CTDFluorouracil affects the expression of SPARC mRNAPMID:24704097
Sparcincreases response to substanceISOSPARC (Homo sapiens)6480464CTDSPARC protein results in increased susceptibility to FluorouracilPMID:15902309
Sparcmultiple interactionsISOSPARC (Homo sapiens)6480464CTD[decitabine affects the methylation of SPARC promoter] which affects the susceptibility to FluorouracilPMID:18458674
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