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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3540
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rb1
Name: RB transcriptional corepressor 1
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rb1affects expressionISORB1 (Homo sapiens)6480464CTDFluorouracil affects the expression of RB1 mRNAPMID:15205334
Rb1affects response to substanceISORb1 (Mus musculus)6480464CTDRB1 protein affects the susceptibility to FluorouracilPMID:15064736
Rb1affects response to substanceISORB1 (Homo sapiens)6480464CTDRB1 protein affects the susceptibility to Fluorouracil; RB1 protein modified form affects the susceptibility to FluorouracilPMID:17640669 PMID:18383818
Rb1increases phosphorylationISORB1 (Homo sapiens)6480464CTDFluorouracil results in increased phosphorylation of RB1 proteinPMID:9930367
Rb1multiple interactionsISORB1 (Homo sapiens)6480464CTDFluorouracil results in increased expression of and results in increased phosphorylation of RB1 protein; RB1 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine]PMID:17207318 PMID:18678097
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