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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1606836
Species: Homo sapiens
RGD Object: Gene
Symbol: PLOD2
Name: procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PLOD2affects response to substanceEXP 6480464CTDPLOD2 protein affects the susceptibility to FluorouracilPMID:15352031
PLOD2decreases expressionEXP 6480464CTDFluorouracil results in decreased expression of PLOD2 mRNAPMID:16557594
PLOD2increases expressionEXP 6480464CTDFluorouracil results in increased expression of PLOD2 proteinPMID:15352031
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