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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1593768
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rbbp4
Name: RB binding protein 4, chromatin remodeling factor
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rbbp4decreases expressionISORBBP4 (Homo sapiens)6480464CTDFluorouracil results in decreased expression of RBBP4 mRNAPMID:16557594
Rbbp4multiple interactionsISORBBP4 (Homo sapiens)6480464CTDRBBP4 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine]PMID:18678097
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