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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1549988
Species: Mus musculus
RGD Object: Gene
Symbol: Tlr9
Name: toll-like receptor 9
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tlr9increases secretionEXP 6480464CTDFluorouracil results in increased secretion of TLR9 proteinPMID:32314717
Tlr9multiple interactionsEXP 6480464CTDHydroxychloroquine inhibits the reaction [Fluorouracil results in increased secretion of TLR9 protein]PMID:32314717
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