Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	1352582
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	IL6
Name:	interleukin 6

Acc ID:	CHEBI:46345
Term:	5-fluorouracil
Definition:	A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID:	MESH:D005472

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
IL6	increases expression	EXP		6480464	CTD	Fluorouracil results in increased expression of IL6 mRNA	PMID:35147423
IL6	increases secretion	EXP		6480464	CTD	Fluorouracil results in increased secretion of IL6 protein	PMID:35147423
IL6	multiple interactions	EXP		6480464	CTD	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Fluorouracil results in increased expression of IL6 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Fluorouracil results in increased secretion of IL6 protein]; [Fluorouracil co-treated with IL6 protein] results in increased expression of MT2A mRNA; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Fluorouracil results in increased expression of IL6 mRNA]; IL6 promoter polymorphism affects the susceptibility to [Fluorouracil co-treated with Cisplatin]; IL6 protein inhibits the reaction [Fluorouracil results in decreased expression of MT2A protein]; IL6 protein inhibits the reaction [Fluorouracil results in increased cleavage of PARP1 protein]; IL6 protein inhibits the reaction [Fluorouracil results in increased expression of XAF1 mRNA]; IL6 protein inhibits the reaction [Fluorouracil results in increased expression of XAF1 protein]; pyrazolanthrone inhibits the reaction [Fluorouracil results in increased expression of IL6 mRNA]; SB 203580 inhibits the reaction [Fluorouracil results in increased expression of IL6 mRNA]	PMID:16820919 PMID:28507149 PMID:35147423
IL6	increases expression	ISO	Il6 (Mus musculus)	6480464	CTD	Fluorouracil results in increased expression of IL6 mRNA	PMID:18344199 PMID:18523641
IL6	increases expression	ISO	Il6 (Rattus norvegicus)	6480464	CTD	Fluorouracil results in increased expression of IL6 protein	PMID:34665902
IL6	multiple interactions	ISO	Il6 (Mus musculus)	6480464	CTD	Fluorouracil promotes the reaction [Valsartan results in decreased secretion of IL6 protein]	PMID:35235860
IL6	multiple interactions	ISO	Il6 (Rattus norvegicus)	6480464	CTD	Fluorouracil inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of IL6 protein]; Thymol inhibits the reaction [Fluorouracil results in increased expression of IL6 protein]	PMID:25824412 PMID:34665902

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