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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1321661
Species: Homo sapiens
RGD Object: Gene
Symbol: CCNA1
Name: cyclin A1
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCNA1affects expressionEXP 6480464CTDFluorouracil affects the expression of CCNA1 mRNA; Fluorouracil affects the expression of CCNA1 proteinPMID:23941782
CCNA1multiple interactionsEXP 6480464CTD[Cadmium Chloride co-treated with Fluorouracil] affects the expression of CCNA1 protein; Cadmium Chloride affects the reaction [Fluorouracil affects the expression of CCNA1 mRNA]; Fluorouracil affects the reaction [Cadmium Chloride affects the expression of CCNA1 mRNA]PMID:23941782
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