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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1320556
Species: Homo sapiens
RGD Object: Gene
Symbol: HTATIP2
Name: HIV-1 Tat interactive protein 2
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HTATIP2multiple interactionsEXP 6480464CTD[Fluorouracil co-treated with irinotecan] results in increased expression of HTATIP2 mRNAPMID:16391804
HTATIP2increases response to substanceISOHtatip2 (Mus musculus)6480464CTDHTATIP2 protein results in increased susceptibility to FluorouracilPMID:16799960
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