GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Egr1 | affects expression | ISO | EGR1 (Homo sapiens) | 6480464 | CTD | Fluorouracil affects the expression of EGR1 mRNA | PMID:15205334 PMID:16557594 | Egr1 | affects localization | ISO | EGR1 (Homo sapiens) | 6480464 | CTD | Fluorouracil affects the localization of EGR1 protein | PMID:18757417 | Egr1 | decreases expression | ISO | EGR1 (Homo sapiens) | 6480464 | CTD | Fluorouracil results in decreased expression of EGR1 mRNA | PMID:17039268 | Egr1 | increases expression | ISO | EGR1 (Homo sapiens) | 6480464 | CTD | Fluorouracil results in increased expression of EGR1 mRNA | PMID:18757417 | Egr1 | multiple interactions | ISO | EGR1 (Homo sapiens) | 6480464 | CTD | EGR1 protein affects the reaction [Fluorouracil results in increased expression of THBS1 mRNA]; EGR1 protein affects the reaction [Fluorouracil results in increased expression of THBS1 protein]; Fluorouracil promotes the reaction [EGR1 protein binds to THBS1 promoter]; SB 203580 inhibits the reaction [Fluorouracil results in increased expression of EGR1 mRNA]; SB 203580 inhibits the reaction [Fluorouracil results in increased expression of EGR1 protein] | PMID:18757417 | |
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