Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733453
Species: Homo sapiens
RGD Object: Gene
Symbol: FABP4
Name: fatty acid binding protein 4
Acc ID: CHEBI:4629
Term: diosgenin
Definition: A sapogenin that is spirostan which is substituted by a hydroxy group at the 3beta position, contains a double bond at the 5-6 position, and has R- configuration at position 25. A natural product found in Dioscorea (wild yam) species, it is used as the starting point for the commercial synthesis of a number of steroids, including cortisone, pregnenolone and progesterone.
Chemical ID: MESH:D004144
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FABP4decreases expressionISORGD:7334546480464CTDDiosgenin results in decreased expression of FABP4 mRNA

PMID:26408789
FABP4multiple interactionsISORGD:7334546480464CTDDiosgenin inhibits the reaction [Dietary Fats results in increased expression of FABP4 mRNA] fulvestrant inhibits the reaction [Diosgenin results in decreased expression of FABP4 mRNA] PPARG protein inhibits the reaction [Diosgenin results in decreased expression of FABP4 mRNA] rosiglitazone inhibits the reaction [Diosgenin results in decreased expression of FABP4 mRNA]

PMID:26408789
Go Back to source page   Continue to Ontology report