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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732770
Species: Homo sapiens
RGD Object: Gene
Symbol: ABCG8
Name: ATP binding cassette subfamily G member 8
Acc ID: CHEBI:4629
Term: diosgenin
Definition: A sapogenin that is spirostan which is substituted by a hydroxy group at the 3beta position, contains a double bond at the 5-6 position, and has R- configuration at position 25. A natural product found in Dioscorea (wild yam) species, it is used as the starting point for the commercial synthesis of a number of steroids, including cortisone, pregnenolone and progesterone.
Chemical ID: MESH:D004144
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCG8increases expressionISOAbcg8 (Rattus norvegicus)6480464CTDDiosgenin results in increased expression of ABCG8 mRNAPMID:12963437
ABCG8multiple interactionsISOAbcg8 (Rattus norvegicus)6480464CTD[Diosgenin results in increased expression of ABCG8 mRNA] which results in increased secretion of Cholesterol; [Ethinyl Estradiol co-treated with Diosgenin] results in decreased expression of ABCG8 mRNAPMID:12963437 PMID:16105132
ABCG8multiple interactionsISOAbcg8 (Mus musculus)6480464CTDDiosgenin promotes the reaction [ABCG8 protein results in increased secretion of Cholesterol]PMID:15611112
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