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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69168
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARG
Name: peroxisome proliferator activated receptor gamma
Acc ID: CHEBI:4629
Term: diosgenin
Definition: A sapogenin that is spirostan which is substituted by a hydroxy group at the 3beta position, contains a double bond at the 5-6 position, and has R- configuration at position 25. A natural product found in Dioscorea (wild yam) species, it is used as the starting point for the commercial synthesis of a number of steroids, including cortisone, pregnenolone and progesterone.
Chemical ID: MESH:D004144
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARGdecreases expressionISORGD:691696480464CTDDiosgenin results in decreased expression of PPARG mRNA

PMID:26408789
PPARGdecreases response to substanceISORGD:691696480464CTDPPARG protein results in decreased susceptibility to Diosgenin

PMID:26408789
PPARGincreases expressionISORGD:691696480464CTDDiosgenin results in increased expression of PPARG protein

PMID:24001619
PPARGmultiple interactionsISORGD:691696480464CTD[Diosgenin inhibits the reaction [RXRA protein binds to PPARG protein]] which results in decreased activity of PPARG protein Diosgenin inhibits the reaction [Dietary Fats results in increased expression of PPARG mRNA] Diosgenin inhibits the reaction [RXRA protein binds to PPARG protein] fulvestrant inhibits the reaction [Diosgenin results in decreased expression of PPARG mRNA] PPARG protein inhibits the reaction [Diosgenin results in decreased expression of FABP4 mRNA] PPARG protein inhibits the reaction [Diosgenin results in decreased expression of PPARG mRNA]

PMID:26408789
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