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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348437
Species: Homo sapiens
RGD Object: Gene
Symbol: MMP9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:4629
Term: diosgenin
Definition: A sapogenin that is spirostan which is substituted by a hydroxy group at the 3beta position, contains a double bond at the 5-6 position, and has R- configuration at position 25. A natural product found in Dioscorea (wild yam) species, it is used as the starting point for the commercial synthesis of a number of steroids, including cortisone, pregnenolone and progesterone.
Chemical ID: MESH:D004144
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MMP9multiple interactionsEXP 6480464CTDDiosgenin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]

PMID:16331273
MMP9decreases activityISORGD:6213206480464CTDDiosgenin results in decreased activity of MMP9 protein

PMID:21814480
MMP9decreases expressionISORGD:6213206480464CTDDiosgenin results in decreased expression of MMP9 mRNA

PMID:21814480
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