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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344192
Species: Homo sapiens
RGD Object: Gene
Symbol: TNF
Name: tumor necrosis factor
Acc ID: CHEBI:4629
Term: diosgenin
Definition: A sapogenin that is spirostan which is substituted by a hydroxy group at the 3beta position, contains a double bond at the 5-6 position, and has R- configuration at position 25. A natural product found in Dioscorea (wild yam) species, it is used as the starting point for the commercial synthesis of a number of steroids, including cortisone, pregnenolone and progesterone.
Chemical ID: MESH:D004144
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFdecreases activityEXP 6480464CTDDiosgenin results in decreased activity of TNF protein

PMID:16331273
TNFmultiple interactionsEXP 6480464CTDDiosgenin inhibits the reaction [TNF protein results in increased activity of AKT1 protein] Diosgenin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] Diosgenin inhibits the reaction [TNF protein results in increased activity of RELA protein] Diosgenin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein] Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2 protein] Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein] Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein] Diosgenin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein] Diosgenin inhibits the reaction [TNF protein results in increased expression of CCND1 protein] Diosgenin inhibits the reaction [TNF protein results in increased expression of CFLAR protein] Diosgenin inhibits the reaction [TNF protein results in increased expression of MMP9 protein] Diosgenin inhibits the reaction [TNF protein results in increased expression of MYC protein] Diosgenin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] Diosgenin inhibits the reaction [TNF protein results in increased expression of VEGFA protein] Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein] Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]

PMID:16331273
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