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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736060
Species: Homo sapiens
RGD Object: Gene
Symbol: GSTM1
Name: glutathione S-transferase mu 1
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSTM1decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of GSTM1 mRNAPMID:29067470
GSTM1multiple interactionsEXP 6480464CTDGSTM1 protein inhibits the reaction [[CYP2E1 protein co-treated with CYP1A2 protein] results in increased susceptibility to Acetaminophen]PMID:28762043
GSTM1decreases expressionISOGstm1 (Mus musculus)6480464CTDAcetaminophen results in decreased expression of GSTM1 mRNAPMID:16611625
GSTM1decreases expressionISOGstm1 (Rattus norvegicus)6480464CTDAcetaminophen results in decreased expression of GSTM1 mRNAPMID:33387578
GSTM1increases expressionISOGstm1 (Rattus norvegicus)6480464CTDAcetaminophen results in increased expression of GSTM1 mRNAPMID:30723492
GSTM1increases response to substanceISOGstm1 (Mus musculus)6480464CTDGSTM1 results in increased susceptibility to AcetaminophenPMID:22687999
GSTM1multiple interactionsISOGstm1 (Mus musculus)6480464CTD[CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of GSTM1 protein; GSTM1 gene mutant form inhibits the reaction [Acetaminophen results in increased phosphorylation of GSK3B protein]; GSTM1 gene mutant form inhibits the reaction [Acetaminophen results in increased phosphorylation of MAP2K4 protein]PMID:22687999 PMID:25499718
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