GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | GSTM1 | decreases expression | EXP | | 6480464 | CTD | Acetaminophen results in decreased expression of GSTM1 mRNA | PMID:29067470 | GSTM1 | multiple interactions | EXP | | 6480464 | CTD | GSTM1 protein inhibits the reaction [[CYP2E1 protein co-treated with CYP1A2 protein] results in increased susceptibility to Acetaminophen] | PMID:28762043 | GSTM1 | decreases expression | ISO | Gstm1 (Mus musculus) | 6480464 | CTD | Acetaminophen results in decreased expression of GSTM1 mRNA | PMID:16611625 | GSTM1 | decreases expression | ISO | Gstm1 (Rattus norvegicus) | 6480464 | CTD | Acetaminophen results in decreased expression of GSTM1 mRNA | PMID:33387578 | GSTM1 | increases expression | ISO | Gstm1 (Rattus norvegicus) | 6480464 | CTD | Acetaminophen results in increased expression of GSTM1 mRNA | PMID:30723492 | GSTM1 | increases response to substance | ISO | Gstm1 (Mus musculus) | 6480464 | CTD | GSTM1 results in increased susceptibility to Acetaminophen | PMID:22687999 | GSTM1 | multiple interactions | ISO | Gstm1 (Mus musculus) | 6480464 | CTD | [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of GSTM1 protein; GSTM1 gene mutant form inhibits the reaction [Acetaminophen results in increased phosphorylation of GSK3B protein]; GSTM1 gene mutant form inhibits the reaction [Acetaminophen results in increased phosphorylation of MAP2K4 protein] | PMID:22687999 PMID:25499718 | |
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