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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732912
Species: Homo sapiens
RGD Object: Gene
Symbol: GNMT
Name: glycine N-methyltransferase
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GNMTdecreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of GNMT mRNAPMID:26690555 PMID:29067470
GNMTaffects expressionISOGnmt (Mus musculus)6480464CTDAcetaminophen affects the expression of GNMT mRNAPMID:17562736
GNMTaffects expressionISOGnmt (Rattus norvegicus)6480464CTDAcetaminophen affects the expression of GNMT mRNA; Acetaminophen affects the expression of GNMT proteinPMID:16687475 PMID:19103213
GNMTdecreases expressionISOGnmt (Mus musculus)6480464CTDAcetaminophen results in decreased expression of GNMT mRNAPMID:29246445
GNMTdecreases expressionISOGnmt (Rattus norvegicus)6480464CTDAcetaminophen results in decreased expression of GNMT mRNAPMID:18346771
GNMTmultiple interactionsISOGnmt (Mus musculus)6480464CTD[Clofibrate co-treated with Acetaminophen] affects the expression of GNMT mRNA; PANX1 gene mutant form inhibits the reaction [Acetaminophen results in decreased expression of GNMT mRNA]; PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of GNMT mRNA]PMID:17585979 PMID:29246445
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