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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732911
Species: Mus musculus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin dependent kinase inhibitor 1A
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1aaffects expressionEXP 6480464CTDAcetaminophen affects the expression of CDKN1A mRNAPMID:15606129 PMID:17562736
Cdkn1aincreases expressionEXP 6480464CTDAcetaminophen results in increased expression of CDKN1A mRNA; Acetaminophen results in increased expression of CDKN1A proteinPMID:11264010 PMID:12958197 PMID:18469330 PMID:19420014 PMID:20123758 PMID:25319358 PMID:25956474 PMID:26056430 PMID:29540258
Cdkn1amultiple interactionsEXP 6480464CTD[Acetaminophen co-treated with Ozone] results in increased expression of CDKN1A mRNA; [Clofibrate co-treated with Acetaminophen] affects the expression of CDKN1A mRNA; [cobra venom factor co-treated with Acetaminophen] results in increased expression of CDKN1A mRNA; PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CDKN1A mRNA]; schizandrol B inhibits the reaction [Acetaminophen results in increased activity of CDKN1A protein]; schizandrol B inhibits the reaction [Acetaminophen results in increased expression of CDKN1A protein]; SERPINE1 protein affects the reaction [Acetaminophen results in increased expression of CDKN1A mRNA]PMID:17585979 PMID:18469330 PMID:20123758 PMID:22319198 PMID:25319358
Cdkn1aaffects expressionISOCdkn1a (Rattus norvegicus)6480464CTDAcetaminophen affects the expression of CDKN1A mRNAPMID:33387578
Cdkn1aaffects expressionISOCDKN1A (Homo sapiens)6480464CTDAcetaminophen affects the expression of CDKN1A mRNAPMID:11896290
Cdkn1adecreases expressionISOCdkn1a (Rattus norvegicus)6480464CTDAcetaminophen results in decreased expression of CDKN1A mRNA; Acetaminophen results in decreased expression of CDKN1A proteinPMID:16330492 PMID:30723492
Cdkn1aincreases expressionISOCdkn1a (Rattus norvegicus)6480464CTDAcetaminophen results in increased expression of CDKN1A mRNA; Acetaminophen results in increased expression of CDKN1A proteinPMID:23411599 PMID:26011634 PMID:26558467 PMID:32479839
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTDAcetaminophen results in increased expression of CDKN1A mRNAPMID:21420995 PMID:22230336 PMID:29067470 PMID:30008028
Cdkn1aincreases phosphorylationISOCdkn1a (Rattus norvegicus)6480464CTDAcetaminophen results in increased phosphorylation of CDKN1A proteinPMID:26011634
Cdkn1amultiple interactionsISOCdkn1a (Rattus norvegicus)6480464CTDChlormethiazole inhibits the reaction [Acetaminophen results in increased degradation of CDKN1A protein]PMID:16330492
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