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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732480
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPB1
Name: heat shock protein family B (small) member 1
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPB1decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of HSPB1 mRNAPMID:29067470
HSPB1affects expressionISOHspb1 (Mus musculus)6480464CTDAcetaminophen affects the expression of HSPB1 mRNAPMID:17562736
HSPB1increases expressionISOHspb1 (Mus musculus)6480464CTDAcetaminophen results in increased expression of HSPB1 mRNA; Acetaminophen results in increased expression of HSPB1 proteinPMID:11264010 PMID:11743745 PMID:12051698 PMID:15010265 PMID:18544908
HSPB1multiple interactionsISOHspb1 (Mus musculus)6480464CTDPTGS2 protein affects the reaction [Acetaminophen results in increased expression of HSPB1 mRNA]; S100A9 protein inhibits the reaction [Acetaminophen results in increased expression of HSPB1 protein]PMID:11743745 PMID:12051698
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