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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732061
Species: Homo sapiens
RGD Object: Gene
Symbol: CDK4
Name: cyclin dependent kinase 4
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDK4decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of CDK4 mRNAPMID:11793227
CDK4affects expressionISOCdk4 (Mus musculus)6480464CTDAcetaminophen affects the expression of CDK4 mRNAPMID:17562736
CDK4decreases expressionISOCdk4 (Rattus norvegicus)6480464CTDAcetaminophen results in decreased expression of CDK4 mRNAPMID:33387578
CDK4decreases expressionISOCdk4 (Mus musculus)6480464CTDAcetaminophen results in decreased expression of CDK4 proteinPMID:25319358 PMID:25956474
CDK4increases expressionISOCdk4 (Mus musculus)6480464CTDAcetaminophen results in increased expression of CDK4 proteinPMID:28123000
CDK4multiple interactionsISOCdk4 (Mus musculus)6480464CTDAcetaminophen promotes the reaction [[CCND1 protein binds to and results in increased activity of CDK4 protein] which results in increased phosphorylation of RB1 protein]; Canertinib inhibits the reaction [Acetaminophen promotes the reaction [[CCND1 protein binds to and results in increased activity of CDK4 protein] which results in increased phosphorylation of RB1 protein]]; Canertinib inhibits the reaction [Acetaminophen results in increased expression of CDK4 protein]; YAP1 gene mutant form promotes the reaction [Acetaminophen results in increased expression of CDK4 protein]PMID:28123000 PMID:34546377
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