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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731542
Species: Homo sapiens
RGD Object: Gene
Symbol: NOX4
Name: NADPH oxidase 4
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOX4decreases expressionISONox4 (Rattus norvegicus)6480464CTDAcetaminophen results in decreased expression of NOX4 mRNAPMID:15976192 PMID:17202762 PMID:30723492 PMID:32479839
NOX4increases expressionISONox4 (Mus musculus)6480464CTDAcetaminophen results in increased expression of NOX4 proteinPMID:27866976
NOX4multiple interactionsISONox4 (Mus musculus)6480464CTDrosiglitazone inhibits the reaction [Acetaminophen results in increased expression of NOX4 protein]PMID:27866976
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