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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731054
Species: Homo sapiens
RGD Object: Gene
Symbol: EPHX2
Name: epoxide hydrolase 2
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EPHX2decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of EPHX2 mRNAPMID:29067470
EPHX2decreases expressionISOEphx2 (Mus musculus)6480464CTDAcetaminophen results in decreased expression of EPHX2 mRNAPMID:29246445
EPHX2increases expressionISOEphx2 (Rattus norvegicus)6480464CTDAcetaminophen results in increased expression of EPHX2 mRNAPMID:33387578
EPHX2multiple interactionsISOEphx2 (Mus musculus)6480464CTD[Clofibrate co-treated with Acetaminophen] affects the expression of EPHX2 mRNA; PANX1 gene mutant form inhibits the reaction [Acetaminophen results in decreased expression of EPHX2 mRNA]; PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of EPHX2 mRNA]PMID:17585979 PMID:29246445
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