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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69408
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lcn2
Name: lipocalin 2
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lcn2affects expressionEXP 6480464CTDAcetaminophen affects the expression of LCN2 mRNAPMID:20623750
Lcn2decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of LCN2 mRNAPMID:33387578
Lcn2affects expressionISOLcn2 (Mus musculus)6480464CTDAcetaminophen affects the expression of LCN2 mRNAPMID:17562736
Lcn2decreases expressionISOLCN2 (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of LCN2 mRNAPMID:27888128
Lcn2decreases secretionISOLCN2 (Homo sapiens)6480464CTDAcetaminophen results in decreased secretion of LCN2 proteinPMID:27888128
Lcn2increases expressionISOLcn2 (Mus musculus)6480464CTDAcetaminophen results in increased expression of LCN2 mRNA; Acetaminophen results in increased expression of LCN2 proteinPMID:20100502 PMID:22461450 PMID:23375450 PMID:29246445 PMID:30099449 PMID:38042273
Lcn2multiple interactionsISOLcn2 (Mus musculus)6480464CTDacetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Acetaminophen results in increased expression of LCN2 protein]; Fomepizole inhibits the reaction [Acetaminophen results in increased expression of LCN2 protein]; IL22 protein promotes the reaction [Acetaminophen results in increased expression of LCN2 mRNA]; LGALS3 protein affects the reaction [Acetaminophen results in increased expression of LCN2 mRNA]; PANX1 gene mutant form inhibits the reaction [Acetaminophen results in increased expression of LCN2 mRNA]; Rotenone inhibits the reaction [Acetaminophen results in increased expression of LCN2 mRNA]; Rotenone inhibits the reaction [Acetaminophen results in increased expression of LCN2 protein]PMID:22461450 PMID:23375450 PMID:29246445 PMID:30099449 PMID:38042273
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