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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69218
Species: Mus musculus
RGD Object: Gene
Symbol: Aldh2
Name: aldehyde dehydrogenase 2, mitochondrial
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDAcetaminophen results in increased expression of ALDH2 protein

PMID:21329376
multiple interactionsEXP 6480464CTD[Clofibrate co-treated with Acetaminophen] affects the expression of ALDH2 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ALDH2 mRNA]

PMID:17585979
affects expressionISORGD:692196480464CTDAcetaminophen affects the expression of ALDH2 mRNA, Acetaminophen affects the expression of ALDH2 protein

PMID:15800402, PMID:16687475
decreases expressionISORGD:692206480464CTDAcetaminophen results in decreased expression of ALDH2 mRNA

PMID:25704631
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.