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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd1decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of CCND1 mRNAPMID:17202759 PMID:32479839 PMID:33387578
Ccnd1affects expressionISOCcnd1 (Mus musculus)6480464CTDAcetaminophen affects the expression of CCND1 mRNAPMID:17562736 PMID:37179516
Ccnd1affects response to substanceISOCCND1 (Homo sapiens)6480464CTDCCND1 gene polymorphism affects the susceptibility to AcetaminophenPMID:26104854
Ccnd1decreases expressionISOCCND1 (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of CCND1 mRNAPMID:21420995
Ccnd1decreases expressionISOCcnd1 (Mus musculus)6480464CTDAcetaminophen results in decreased expression of CCND1 proteinPMID:25956474 PMID:37179516
Ccnd1increases expressionISOCCND1 (Homo sapiens)6480464CTDAcetaminophen results in increased expression of CCND1 mRNAPMID:29067470
Ccnd1increases expressionISOCcnd1 (Mus musculus)6480464CTDAcetaminophen results in increased expression of CCND1 mRNA; Acetaminophen results in increased expression of CCND1 proteinPMID:12958197 PMID:18469330 PMID:25319358 PMID:28123000 PMID:28827156 PMID:32045647
Ccnd1multiple interactionsISOCcnd1 (Mus musculus)6480464CTD[cobra venom factor co-treated with Acetaminophen] results in increased expression of CCND1 mRNA; Acetaminophen affects the reaction [PRKN gene mutant form affects the expression of CCND1 protein]; Acetaminophen promotes the reaction [[CCND1 protein binds to and results in increased activity of CDK4 protein] which results in increased phosphorylation of RB1 protein]; Canertinib inhibits the reaction [Acetaminophen promotes the reaction [[CCND1 protein binds to and results in increased activity of CDK4 protein] which results in increased phosphorylation of RB1 protein]]; Canertinib inhibits the reaction [Acetaminophen results in increased expression of CCND1 protein]; PPARA protein affects the reaction [Acetaminophen results in increased expression of CCND1 mRNA]; PPARA protein affects the reaction [Acetaminophen results in increased expression of CCND1 protein]; Resveratrol inhibits the reaction [Acetaminophen results in decreased expression of CCND1 protein]; schizandrol B promotes the reaction [Acetaminophen results in increased expression of CCND1 protein]; SERPINE1 protein affects the reaction [Acetaminophen results in increased expression of CCND1 mRNA]; SRT1720 promotes the reaction [Acetaminophen results in increased expression of CCND1 protein]; YAP1 gene mutant form promotes the reaction [Acetaminophen results in increased expression of CCND1 protein]PMID:12958197 PMID:18469330 PMID:22319198 PMID:25319358 PMID:25752611 PMID:25956474 PMID:28123000 PMID:28827156 PMID:34546377
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