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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628899
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ripk3
Name: receptor-interacting serine-threonine kinase 3
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ripk3affects expressionISORipk3 (Mus musculus)6480464CTDAcetaminophen affects the expression of RIPK3 mRNAPMID:17562736
Ripk3increases expressionISORIPK3 (Homo sapiens)6480464CTDAcetaminophen results in increased expression of RIPK3 mRNAPMID:26690555 PMID:27761495
Ripk3increases expressionISORipk3 (Mus musculus)6480464CTDAcetaminophen results in increased expression of RIPK3 proteinPMID:24440347 PMID:33370591
Ripk3multiple interactionsISORipk3 (Mus musculus)6480464CTD3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazoleacetic acid methyl ester inhibits the reaction [Acetaminophen results in increased expression of RIPK3 protein]; [Acetaminophen co-treated with Carbon Tetrachloride] results in increased expression of RIPK3 protein; Acetaminophen inhibits the reaction [Acetaminophen results in increased expression of RIPK3 protein]; necrostatin-1 inhibits the reaction [Acetaminophen results in increased expression of RIPK3 protein]PMID:24440347 PMID:29873576 PMID:33370591
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