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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDAcetaminophen affects the expression of DDIT3 mRNA

PMID:15606129, PMID:17562736
affects localizationEXP 6480464CTDAcetaminophen affects the localization of DDIT3 protein

PMID:14747384
increases expressionEXP 6480464CTDAcetaminophen results in increased expression of DDIT3 mRNA, Acetaminophen results in increased expression of DDIT3 protein

PMID:11264010, PMID:12540782, PMID:12958197, PMID:14747384, PMID:18544908, PMID:19931551, PMID:25265579, PMID:25743375
multiple interactionsEXP 6480464CTD[Clofibrate co-treated with Acetaminophen] affects the expression of DDIT3 mRNA, O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1, 2-diolate inhibits the reaction [Acetaminophen results in increased expression of DDIT3 mRNA], PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DDIT3 mRNA], saikosaponin inhibits the reaction [Acetaminophen results in increased expression of DDIT3 mRNA]

PMID:12540782, PMID:17585979, PMID:25265579
increases expressionISORGD:623916480464CTDAcetaminophen results in increased expression of DDIT3 mRNA

PMID:12883083, PMID:17202762, PMID:17522070, PMID:18246545
increases expressionISORGD:691656480464CTDAcetaminophen results in increased expression of DDIT3 mRNA

PMID:21420995, PMID:29067470, PMID:30008028
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.