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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases cleavageISORGD:7314426480464CTDAcetaminophen results in increased cleavage of CASP12 protein

PMID:14747384
increases expressionISORGD:7314426480464CTDAcetaminophen results in increased expression of CASP12 mRNA

PMID:12540782
multiple interactionsISORGD:7314426480464CTDO(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1, 2-diolate inhibits the reaction [Acetaminophen results in increased expression of CASP12 mRNA]

PMID:12540782
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.