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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2906
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcr2
Name: C-X-C motif chemokine receptor 2
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcr2decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of CXCR2 mRNAPMID:33387578
Cxcr2affects expressionISOCxcr2 (Mus musculus)6480464CTDAcetaminophen affects the expression of CXCR2 mRNAPMID:17562736
Cxcr2affects response to substanceISOCxcr2 (Mus musculus)6480464CTDCXCR2 protein affects the susceptibility to AcetaminophenPMID:16552707
Cxcr2increases expressionISOCxcr2 (Mus musculus)6480464CTD[Acetaminophen results in increased expression of CXCL10 protein] which results in increased expression of CXCR2 protein; Acetaminophen results in increased expression of CXCR2 mRNA; Acetaminophen results in increased expression of CXCR2 proteinPMID:11739529 PMID:31444509 PMID:34724096
Cxcr2multiple interactionsISOCxcr2 (Mus musculus)6480464CTDClodronic Acid inhibits the reaction [Acetaminophen results in increased expression of CXCR2 protein]; CXCR2 protein affects the reaction [Acetaminophen results in increased expression of HMOX1 mRNA]; CXCR2 protein affects the reaction [Acetaminophen results in increased expression of NOS2 mRNA]; IL10 protein inhibits the reaction [Clodronic Acid inhibits the reaction [Acetaminophen results in increased expression of CXCR2 protein]]; PTGES2 protein affects the reaction [Acetaminophen results in increased expression of CXCR2 mRNA]PMID:16552707 PMID:31444509 PMID:34724096
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