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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2690
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gja1
Name: gap junction protein, alpha 1
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gja1decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of GJA1 mRNAPMID:33387578
Gja1affects response to substanceISOGja1 (Mus musculus)6480464CTDGJA1 protein affects the susceptibility to AcetaminophenPMID:26912412
Gja1decreases expressionISOGJA1 (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of GJA1 mRNAPMID:26690555
Gja1increases expressionISOGja1 (Mus musculus)6480464CTDAcetaminophen results in increased expression of GJA1 mRNAPMID:26912412
Gja1multiple interactionsISOGja1 (Mus musculus)6480464CTD[GJA1 protein affects the susceptibility to Acetaminophen] which affects the secretion of IFNG protein; [GJA1 protein affects the susceptibility to Acetaminophen] which affects the secretion of IL10 protein; [GJA1 protein affects the susceptibility to Acetaminophen] which affects the secretion of IL1B protein; [GJA1 protein affects the susceptibility to Acetaminophen] which affects the secretion of TNF protein; Acetaminophen results in increased expression of and results in increased phosphorylation of GJA1 proteinPMID:26912412
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