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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of BAX mRNAPMID:20732408
Baxincreases expressionEXP 6480464CTDAcetaminophen results in increased expression of BAX proteinPMID:11562448 PMID:26767949
Baxmultiple interactionsEXP 6480464CTDmorin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]PMID:26767949
Baxaffects expressionISOBax (Mus musculus)6480464CTDAcetaminophen affects the expression of BAX mRNAPMID:17562736
Baxaffects expressionISOBAX (Homo sapiens)6480464CTDAcetaminophen affects the expression of BAX mRNAPMID:20732408
Baxaffects localizationISOBax (Mus musculus)6480464CTDAcetaminophen affects the localization of BAX proteinPMID:17906064 PMID:20423716 PMID:21241727 PMID:21572097 PMID:24440347 PMID:27562556 PMID:27773698 PMID:29739258
Baxaffects response to substanceISOBax (Mus musculus)6480464CTDBAX protein affects the susceptibility to AcetaminophenPMID:17906064
Baxincreases expressionISOBax (Mus musculus)6480464CTDAcetaminophen results in increased expression of BAX mRNA; Acetaminophen results in increased expression of BAX proteinPMID:12540782 PMID:20355050 PMID:22939915 PMID:28435131 PMID:30375433 PMID:31697998 PMID:31967706 PMID:33571619 PMID:35166444 PMID:35179299 PMID:36928416
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDAcetaminophen results in increased expression of BAX mRNA; Acetaminophen results in increased expression of BAX proteinPMID:22230336 PMID:33959992 PMID:33971260
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[celastrol co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; amlexanox inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; celastrol inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]; coomassie Brilliant Blue inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; dioscin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; Fomepizole inhibits the reaction [Acetaminophen affects the localization of BAX protein]; Irbesartan inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; necrostatin-1 inhibits the reaction [Acetaminophen affects the localization of BAX protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]; O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of BAX mRNA]; Plant Extracts inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [Acetaminophen affects the localization of BAX protein]PMID:12540782 PMID:20355050 PMID:20423716 PMID:22939915 PMID:24440347 PMID:28435131 PMID:29739258 PMID:31697998 PMID:31967706 PMID:35166444 PMID:35179299
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Acetaminophen results in increased expression of BAX mRNA]; N-acetylsphingosine promotes the reaction [Acetaminophen results in increased expression of BAX protein]; oltipraz inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of BAX protein]PMID:33959992 PMID:33971260
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