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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2078
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ak4
Name: adenylate kinase 4
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ak4increases expressionEXP 6480464CTDAcetaminophen results in increased expression of AK4 mRNA; Acetaminophen results in increased expression of AK4 proteinPMID:16538043 PMID:33387578
Ak4affects expressionISOAk4 (Mus musculus)6480464CTDAcetaminophen affects the expression of AK4 mRNAPMID:17562736
Ak4decreases expressionISOAK4 (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of AK4 mRNAPMID:25704631 PMID:26690555 PMID:29067470
Ak4increases expressionISOAk4 (Mus musculus)6480464CTDAcetaminophen results in increased expression of AK4 mRNAPMID:29246445
Ak4multiple interactionsISOAk4 (Mus musculus)6480464CTD[Clofibrate co-treated with Acetaminophen] affects the expression of AK4 mRNA; PANX1 gene mutant form inhibits the reaction [Acetaminophen results in increased expression of AK4 mRNA]; PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of AK4 mRNA]PMID:17585979 PMID:29246445
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