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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2065
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Afp
Name: alpha-fetoprotein
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Afpaffects expressionISOAfp (Mus musculus)6480464CTDAcetaminophen affects the expression of AFP mRNAPMID:17562736
Afpdecreases expressionISOAFP (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of AFP mRNA; Acetaminophen results in decreased expression of AFP proteinPMID:22230336 PMID:30008028
Afpincreases expressionISOAfp (Mus musculus)6480464CTDAcetaminophen results in increased expression of AFP mRNA; Acetaminophen results in increased expression of AFP proteinPMID:29246445 PMID:70250
Afpmultiple interactionsISOAfp (Mus musculus)6480464CTDPANX1 gene mutant form inhibits the reaction [Acetaminophen results in increased expression of AFP mRNA]PMID:29246445
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