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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1620890
Species: Mus musculus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP-binding cassette, sub-family B member 1A
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1adecreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of ABCB1A proteinPMID:36073954
Abcb1amultiple interactionsEXP 6480464CTD[Acetaminophen co-treated with Sodium Chloride] results in increased expression of ABCB1A mRNAPMID:17934960
Abcb1aaffects response to substanceISOABCB1 (Homo sapiens)6480464CTDABCB1 protein affects the susceptibility to AcetaminophenPMID:16930294
Abcb1aincreases activityISOABCB1 (Homo sapiens)6480464CTDAcetaminophen results in increased activity of ABCB1 proteinPMID:16930294 PMID:17526808
Abcb1aincreases expressionISOAbcb1a (Rattus norvegicus)6480464CTDAcetaminophen results in increased expression of ABCB1 mRNA; Acetaminophen results in increased expression of ABCB1 protein; Acetaminophen results in increased expression of ABCB1A mRNAPMID:15276087 PMID:15976192 PMID:17522070 PMID:33387578
Abcb1aincreases expressionISOABCB1 (Homo sapiens)6480464CTDAcetaminophen results in increased expression of ABCB1 mRNA; Acetaminophen results in increased expression of ABCB1 proteinPMID:16930294 PMID:17627974 PMID:26690555
Abcb1aincreases transportISOABCB1 (Homo sapiens)6480464CTDABCB1 protein results in increased transport of AcetaminophenPMID:16930294
Abcb1amultiple interactionsISOAbcb1a (Rattus norvegicus)6480464CTDAcetaminophen promotes the reaction [ABCB1 protein results in increased transport of Digoxin]PMID:15276087
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTDAcetaminophen promotes the reaction [ABCB1 protein results in decreased uptake of Doxorubicin]; Verapamil inhibits the reaction [Acetaminophen results in increased activity of ABCB1 protein]PMID:16930294 PMID:17526808
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