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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1614748
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2c54
Name: cytochrome P450, family 2, subfamily c, polypeptide 54
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of CYP2C54 mRNA, Acetaminophen results in decreased expression of CYP2C54 protein

PMID:21329376, PMID:29246445
multiple interactionsEXP 6480464CTDPANX1 gene mutant form inhibits the reaction [Acetaminophen results in decreased expression of CYP2C54 mRNA]

PMID:29246445
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.