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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1342674
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARGC1A
Name: PPARG coactivator 1 alpha
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARGC1Adecreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of PPARGC1A mRNAPMID:29067470
PPARGC1Aaffects expressionISOPpargc1a (Mus musculus)6480464CTDAcetaminophen affects the expression of PPARGC1A mRNAPMID:17562736
PPARGC1Aincreases expressionISOPpargc1a (Mus musculus)6480464CTDAcetaminophen results in increased expression of PPARGC1A proteinPMID:33271250
PPARGC1Amultiple interactionsISOPpargc1a (Mus musculus)6480464CTDAcetaminophen affects the expression of and affects the localization of PPARGC1A protein; SRT1720 affects the reaction [Acetaminophen affects the expression of PPARGC1A protein]PMID:28827156
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