Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1321966
Species: Homo sapiens
RGD Object: Gene
Symbol: PTGES2
Name: prostaglandin E synthase 2
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTGES2decreases expressionISOPtges2 (Rattus norvegicus)6480464CTDAcetaminophen results in decreased expression of PTGES2 mRNAPMID:33387578
PTGES2increases response to substanceISOPtges2 (Mus musculus)6480464CTDPTGES2 protein results in increased susceptibility to AcetaminophenPMID:31444509
PTGES2multiple interactionsISOPtges2 (Mus musculus)6480464CTDPTGES2 protein affects the reaction [Acetaminophen results in increased expression of CXCR2 mRNA]; PTGES2 protein affects the reaction [Acetaminophen results in increased expression of IL1B mRNA]; PTGES2 protein affects the reaction [Acetaminophen results in increased expression of TNF protein]; PTGES2 protein affects the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]; PTGES2 protein affects the reaction [Celecoxib promotes the reaction [Acetaminophen results in increased expression of GPT protein]]; PTGES2 protein promotes the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; PTGES2 protein promotes the reaction [Acetaminophen results in increased expression of CXCL1 mRNA]; PTGES2 protein promotes the reaction [Acetaminophen results in increased expression of CXCL2 mRNA]; PTGES2 protein promotes the reaction [Acetaminophen results in increased expression of GPT protein]; PTGES2 protein promotes the reaction [Acetaminophen results in increased expression of IL1B protein]; PTGES2 protein promotes the reaction [Acetaminophen results in increased expression of IL6 mRNA]; PTGES2 protein promotes the reaction [Acetaminophen results in increased expression of NLRP3 protein]; PTGES2 protein promotes the reaction [Acetaminophen results in increased expression of TNF mRNA]PMID:31444509
Go Back to source page   Continue to Ontology report