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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313517
Species: Homo sapiens
RGD Object: Gene
Symbol: ATF6
Name: activating transcription factor 6
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ATF6affects expressionISOAtf6 (Mus musculus)6480464CTDAcetaminophen affects the expression of ATF6 mRNAPMID:17562736
ATF6increases cleavageISOAtf6 (Mus musculus)6480464CTDAcetaminophen results in increased cleavage of ATF6 proteinPMID:31524377
ATF6increases expressionISOAtf6 (Rattus norvegicus)6480464CTDAcetaminophen results in increased expression of ATF6 mRNAPMID:33387578
ATF6multiple interactionsISOAtf6 (Mus musculus)6480464CTDAcetaminophen results in increased cleavage of and results in increased activity of ATF6 protein; Guanabenz inhibits the reaction [Acetaminophen results in increased cleavage of ATF6 protein]PMID:19931551 PMID:31524377
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