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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305769
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pink1
Name: PTEN induced kinase 1
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pink1decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of PINK1 mRNAPMID:33387578
Pink1affects expressionISOPink1 (Mus musculus)6480464CTDAcetaminophen affects the expression of PINK1 mRNAPMID:17562736
Pink1decreases expressionISOPink1 (Mus musculus)6480464CTDAcetaminophen results in decreased expression of PINK1 mRNAPMID:37179516
Pink1increases expressionISOPINK1 (Homo sapiens)6480464CTDAcetaminophen results in increased expression of PINK1 mRNAPMID:22230336 PMID:25704631
Pink1increases expressionISOPink1 (Mus musculus)6480464CTDAcetaminophen results in increased expression of PINK1 proteinPMID:33271250
Pink1multiple interactionsISOPink1 (Mus musculus)6480464CTDChloroquine inhibits the reaction [Acetaminophen results in increased expression of PINK1 protein]; Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PINK1 protein]]; coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PINK1 protein]PMID:33271250
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