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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11050
Species: Mus musculus
RGD Object: Gene
Symbol: Pah
Name: phenylalanine hydroxylase
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pahaffects expressionEXP 6480464CTDAcetaminophen affects the expression of PAH mRNAPMID:17562736
Pahmultiple interactionsEXP 6480464CTD[CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of PAH proteinPMID:25499718
Pahdecreases expressionISOPAH (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of PAH mRNAPMID:29067470
Pahincreases expressionISOPah (Rattus norvegicus)6480464CTDAcetaminophen results in increased expression of PAH proteinPMID:16538041
Pahincreases expressionISOPAH (Homo sapiens)6480464CTDAcetaminophen results in increased expression of PAH mRNAPMID:26690555
Pahmultiple interactionsISOPAH (Homo sapiens)6480464CTD[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of PAH mRNAPMID:33819548
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