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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10681
Species: Mus musculus
RGD Object: Gene
Symbol: Gpx1
Name: glutathione peroxidase 1
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx1affects response to substanceEXP 6480464CTDGPX1 protein affects the susceptibility to AcetaminophenPMID:16636302
Gpx1decreases activityEXP 6480464CTDAcetaminophen results in decreased activity of GPX1 proteinPMID:16831125
Gpx1decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of GPX1 mRNAPMID:19799668 PMID:29246445
Gpx1decreases response to substanceEXP 6480464CTDGPX1 results in decreased susceptibility to AcetaminophenPMID:16831125
Gpx1increases expressionEXP 6480464CTDAcetaminophen results in increased expression of GPX1 mRNAPMID:31077331 PMID:33271250
Gpx1multiple interactionsEXP 6480464CTD[CAT protein affects the susceptibility to Acetaminophen] which affects the expression of GPX1 mRNA; [GPX1 protein co-treated with SOD1 protein] affects the reaction [Acetaminophen results in decreased abundance of Glutathione]; [GPX1 protein co-treated with SOD1 protein] affects the susceptibility to Acetaminophen; Carnosine inhibits the reaction [Acetaminophen results in decreased expression of GPX1 mRNA]; coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of GPX1 mRNA]; GPX1 protein affects the reaction [Acetaminophen results in decreased abundance of Glutathione]; PANX1 gene mutant form inhibits the reaction [Acetaminophen results in decreased expression of GPX1 mRNA]; SIRT1 affects the reaction [Acetaminophen results in increased expression of GPX1 mRNA]PMID:16636302 PMID:19799668 PMID:29246445 PMID:31077331 PMID:33271250 PMID:34390818
Gpx1decreases activityISOGpx1 (Rattus norvegicus)6480464CTDAcetaminophen results in decreased activity of GPX1 proteinPMID:15707775
Gpx1decreases expressionISOGpx1 (Rattus norvegicus)6480464CTDAcetaminophen results in decreased expression of GPX1 mRNAPMID:17522070 PMID:33387578
Gpx1decreases expressionISOGPX1 (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of GPX1 mRNAPMID:31059760
Gpx1increases expressionISOGpx1 (Rattus norvegicus)6480464CTDAcetaminophen results in increased expression of GPX1 proteinPMID:15800402
Gpx1increases expressionISOGPX1 (Homo sapiens)6480464CTDAcetaminophen results in increased expression of GPX1 mRNAPMID:31077331
Gpx1multiple interactionsISOGpx1 (Rattus norvegicus)6480464CTDAcetaminophen results in decreased expression of and results in decreased activity of GPX1 protein; isocytisoside inhibits the reaction [Acetaminophen results in decreased activity of GPX1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Acetaminophen results in decreased expression of and results in decreased activity of GPX1 protein]PMID:15707775 PMID:24910983
Gpx1multiple interactionsISOGPX1 (Homo sapiens)6480464CTD[Acetaminophen co-treated with Lipopolysaccharides] results in decreased expression of GPX1 mRNA; SIRT1 affects the reaction [Acetaminophen results in increased expression of GPX1 mRNA]PMID:31059760 PMID:31077331
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