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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10090
Species: Mus musculus
RGD Object: Gene
Symbol: Adh1
Name: alcohol dehydrogenase 1 (class I)
Acc ID: CHEBI:46081
Term: fluconazole
Definition: A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.
Chemical ID: MESH:D015725
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adh1decreases expressionISOAdh1c (Rattus norvegicus)6480464CTDFluconazole results in decreased expression of ADH1 mRNAPMID:16643972
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