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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732174
Species: Homo sapiens
RGD Object: Gene
Symbol: BCHE
Name: butyrylcholinesterase
Acc ID: CHEBI:4604
Term: dimenhydrinate
Definition: The diphenhydramine salt of 8-chlorotheophylline. Its effects are similar to those of diphenhydramine, but it is less potent. It was thought that by combining the antiemetic effects of diphenhydramine with the mild stimulant effects of 8-chlorotheophyline, the extreme drowsiness induced by the former would be mitigated. However, the sedation caused by diphenhydramine is considerably stronger than the stimulation caused by 8-chlorotheophylline. Dimenhydrinate is used mainly as an antiemetic in the prevention and treatment of motion sickness.
Chemical ID: MESH:D004111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BCHEdecreases activityEXP 6480464CTDDimenhydrinate results in decreased activity of BCHE proteinPMID:236606
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