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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731712
Species: Homo sapiens
RGD Object: Gene
Symbol: RB1
Name: RB transcriptional corepressor 1
Acc ID: CHEBI:46024
Term: trichostatin A
Definition: A trichostatin that has formula 302.36826.
Chemical ID: MESH:C012589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RB1affects expressionEXP 6480464CTD[trichostatin A affects the expression of DNMT3B protein] which affects the expression of RB1 mRNAPMID:18544619
RB1decreases activityEXP 6480464CTDtrichostatin A results in decreased activity of RB1 proteinPMID:15494029
RB1increases expressionEXP 6480464CTDtrichostatin A results in increased expression of RB1 mRNAPMID:24935251
RB1multiple interactionsEXP 6480464CTDtrichostatin A results in decreased phosphorylation of and results in increased expression of RB1 proteinPMID:15179185
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