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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731081
Species: Homo sapiens
RGD Object: Gene
Symbol: PGR
Name: progesterone receptor
Acc ID: CHEBI:46024
Term: trichostatin A
Definition: A trichostatin that has formula 302.36826.
Chemical ID: MESH:C012589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDtrichostatin A results in increased expression of PGR mRNA, trichostatin A results in increased expression of PGR mRNA alternative form, trichostatin A results in increased expression of PGR protein alternative form

PMID:16024066, PMID:24935251, PMID:27188386
multiple interactionsEXP 6480464CTD[decitabine co-treated with trichostatin A] affects the expression of PGR mRNA, [decitabine co-treated with trichostatin A] results in increased expression of PGR mRNA, [trichostatin A co-treated with decitabine] results in increased expression of PGR mRNA alternative form, [trichostatin A co-treated with decitabine] results in increased expression of PGR protein alternative form

PMID:16024066, PMID:17533736, PMID:18264725
multiple interactionsISORGD:110926480464CTD[estradiol dipropionate co-treated with trichostatin A] results in decreased expression of PGR protein

PMID:15930180
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.