Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69115
Species: Homo sapiens
RGD Object: Gene
Symbol: CDKN1B
Name: cyclin dependent kinase inhibitor 1B
Acc ID: CHEBI:46024
Term: trichostatin A
Definition: A trichostatin that has formula 302.36826.
Chemical ID: MESH:C012589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDKN1Baffects expressionEXP 6480464CTD[trichostatin A affects the expression of DNMT3B protein] which affects the expression of CDKN1B mRNAPMID:18544619
CDKN1Bincreases expressionEXP 6480464CTDtrichostatin A results in increased expression of CDKN1B mRNA; trichostatin A results in increased expression of CDKN1B proteinPMID:17431121 PMID:23770000
CDKN1Bmultiple interactionsEXP 6480464CTD[decitabine co-treated with trichostatin A] results in increased expression of CDKN1B mRNA; Tretinoin promotes the reaction [trichostatin A results in increased expression of CDKN1B mRNA]; Tretinoin promotes the reaction [trichostatin A results in increased expression of CDKN1B protein]PMID:17185465 PMID:17431121
Go Back to source page   Continue to Ontology report