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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620259
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif4ebp1
Name: eukaryotic translation initiation factor 4E binding protein 1
Acc ID: CHEBI:46024
Term: trichostatin A
Definition: A trichostatin that has formula 302.36826.
Chemical ID: MESH:C012589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif4ebp1increases expressionISOEIF4EBP1 (Homo sapiens)6480464CTDtrichostatin A results in increased expression of EIF4EBP1 mRNAPMID:24935251 PMID:26272509
Eif4ebp1multiple interactionsISOEIF4EBP1 (Homo sapiens)6480464CTD[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EIF4EBP1 mRNA; [trichostatin A co-treated with Bortezomib] results in decreased phosphorylation of EIF4EBP1 proteinPMID:21345073 PMID:27188386
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