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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2200
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2l1
Name: Bcl2-like 1
Acc ID: CHEBI:46024
Term: trichostatin A
Definition: A trichostatin that has formula 302.36826.
Chemical ID: MESH:C012589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2l1decreases expressionEXP 6480464CTDtrichostatin A results in decreased expression of BCL2L1 mRNAPMID:23558232
Bcl2l1decreases response to substanceEXP 6480464CTDBCL2L1 gene mutant form results in decreased susceptibility to trichostatin APMID:10970895
Bcl2l1affects expressionISOBCL2L1 (Homo sapiens)6480464CTDtrichostatin A affects the expression of BCL2L1 mRNAPMID:28542535
Bcl2l1decreases expressionISOBCL2L1 (Homo sapiens)6480464CTDtrichostatin A results in decreased expression of BCL2L1 proteinPMID:16009488 PMID:19887557
Bcl2l1decreases response to substanceISOBCL2L1 (Homo sapiens)6480464CTDBCL2L1 protein results in decreased susceptibility to trichostatin APMID:15781649
Bcl2l1multiple interactionsISOBCL2L1 (Homo sapiens)6480464CTDBCL2L1 protein results in decreased susceptibility to [Bortezomib co-treated with trichostatin A]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2L1 protein]]; SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2L1 protein]; trichostatin A promotes the reaction [Bortezomib results in decreased expression of BCL2L1 mRNA]; trichostatin A promotes the reaction [Bortezomib results in decreased expression of BCL2L1 protein]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2L1 protein]]]PMID:16904634 PMID:19887557
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