GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sp1 | affects expression | ISO | SP1 (Homo sapiens) | 6480464 | CTD | trichostatin A affects the expression of SP1 mRNA; trichostatin A affects the expression of SP1 protein | PMID:18801729 | Sp1 | increases activity | ISO | SP1 (Homo sapiens) | 6480464 | CTD | trichostatin A results in increased activity of SP1 protein | PMID:16757381 | Sp1 | multiple interactions | ISO | SP1 (Homo sapiens) | 6480464 | CTD | [[decitabine co-treated with trichostatin A] promotes the reaction [SP1 protein binds to SLC25A1 promoter]] which results in increased expression of SLC25A1 mRNA; [decitabine co-treated with trichostatin A] promotes the reaction [SP1 protein binds to CLDN3 promoter]; SP1 protein affects the reaction [trichostatin A affects the expression of GDF15 mRNA]; trichostatin A inhibits the reaction [Lipopolysaccharides results in increased expression of SP1 mRNA]; trichostatin A promotes the reaction [SP1 protein binds to PDK4 promoter]; trichostatin A promotes the reaction [SP1 protein binds to SLC25A1 promoter]; trichostatin A promotes the reaction [Tretinoin promotes the reaction [SP1 protein binds to FOLR2 promoter]] | PMID:16740727 PMID:16757381 PMID:17986852 PMID:18706393 PMID:18801729 PMID:21911040 | | ||||||||||||||||||||||
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