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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735878
Species: Homo sapiens
RGD Object: Gene
Symbol: ACHE
Name: acetylcholinesterase (Yt blood group)
Acc ID: CHEBI:45980
Term: tacrine
Definition: A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
Chemical ID: MESH:D013619
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACHEdecreases activityEXP 6480464CTDTacrine results in decreased activity of ACHE proteinPMID:2606156 PMID:29131470 PMID:29975450 PMID:29992664 PMID:31581370 PMID:33844597 PMID:9228650
ACHEmultiple interactionsEXP 6480464CTDALB protein affects the reaction [Tacrine results in decreased activity of ACHE protein]PMID:26902639
ACHEdecreases activityISOAche (Rattus norvegicus)6480464CTDTacrine analog results in decreased activity of ACHE protein; Tacrine results in decreased activity of ACHE proteinPMID:12589378 PMID:18571635 PMID:19053746
ACHEdecreases activityISOAche (Mus musculus)6480464CTDTacrine results in decreased activity of ACHE proteinPMID:15990178 PMID:19365154
ACHEmultiple interactionsISOAche (Mus musculus)6480464CTDTacrine inhibits the reaction [Scopolamine results in increased expression of ACHE protein]PMID:31077737
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