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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:45980
Term: tacrine
Definition: A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
Chemical ID: MESH:D013619
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDTacrine results in decreased activity of NQO1 protein

PMID:29281794
multiple interactionsEXP 6480464CTDTacrine inhibits the reaction [NQO1 protein results in increased reduction of 2, 6-Dichloroindophenol]

PMID:29281794
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.